发明授权
US4137318A N-(phenylalkylamino-alkyl)-dihydroisoquinolinones, pharmaceutical
compositions and methods employing them
失效
N-（苯基烷基氨基 - 烷基） - 二氢异喹啉酮，药物组合物和采用它们的方法
- 专利标题： N-(phenylalkylamino-alkyl)-dihydroisoquinolinones, pharmaceutical compositions and methods employing them
- 专利标题（中）： N-（苯基烷基氨基 - 烷基） - 二氢异喹啉酮，药物组合物和采用它们的方法
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申请号： US826853申请日： 1977-08-22
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公开(公告)号： US4137318A公开(公告)日： 1979-01-30
- 发明人: Wolfgang Eberlein , Joachim Heider , Volkhard Austel , Jurgen Dammgen , Rudolf Kadatz
- 申请人： Wolfgang Eberlein , Joachim Heider , Volkhard Austel , Jurgen Dammgen , Rudolf Kadatz
- 申请人地址： DE1 Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim GmbH
- 当前专利权人： Boehringer Ingelheim GmbH
- 当前专利权人地址： DE1 Ingelheim am Rhein
- 优先权： DEX2639718 19760903
- 主分类号： C07D209/44
- IPC分类号： C07D209/44 ; A61K31/47 ; A61K31/472 ; A61K31/55 ; A61P9/00 ; A61P9/12 ; C07C217/04 ; C07D217/06 ; C07D217/24 ; C07D217/26 ; C07D223/16 ; C07D491/056
摘要：
Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.6, which may be identical to or different from each other, are each hydrogen or lower alkyl;R.sub.3 is lower alkoxy;R.sub.4 is lower alkoxy or, together with R.sub.3, methylenedioxy or ethylenedioxy;R.sub.5 is hydrogen, lower alkyl or benzyl;R.sub.7 is hydrogen or lower alkoxy;R.sub.8 is hydrogen, lower alkoxy or, together with R.sub.7, methylenedioxy or ethylenedioxy;M is 1 or 2; andN is 2 or 3;And non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antihypertensives and heart rate reducers.
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