发明授权
- 专利标题: Cyclization to form cephem ring and intermediates therefor
- 专利标题(中): 环化形成头孢烯环及其中间体
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申请号: US856806申请日: 1977-12-01
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公开(公告)号: US4160085A公开(公告)日: 1979-07-03
- 发明人: Teruji Tsuji , Yoshio Hamashima , Mitsuru Yoshioka , Masayuki Narisada , Hiroshi Tanida , Taichiro Komeno , Wataru Nagata
- 申请人: Teruji Tsuji , Yoshio Hamashima , Mitsuru Yoshioka , Masayuki Narisada , Hiroshi Tanida , Taichiro Komeno , Wataru Nagata
- 申请人地址: JPX Osaka
- 专利权人: Shionogi & Co., Ltd.
- 当前专利权人: Shionogi & Co., Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX50-19612 19750217; JPX50-22229 19750221; JPX50-28452 19750307; JPX50-33808 19750330
- 主分类号: C07D205/095
- IPC分类号: C07D205/095 ; C07D501/08 ; C07D501/10 ; C07D501/20 ; C07D501/59 ; C07D501/02
摘要:
Intermediates represented by the following formulas are useful for synthesizing 3-hydroxy-3-cephem compounds ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidinothiazoline bicyclic ring; and the enamine derivatives thereof. One embodiment provides for cyclizing a compound of the formula: ##STR2## wherein A, B, X and Hal are as defined above, which comprises treating the said compound with an acid, base, or solvent if required in the presence of a catalyzer to give a compound represented by following formula ##STR3## In a further embodiment a compound represented by the following formula ##STR4## wherein A, B, R and X are as defined above, is prepared by a process which comprises treating an enamine of a compound represented by following formula ##STR5## wherein A, B, R, X, Hal and broken line are as defined above, with a disubstituted amino containing from 2 to 20 carbon atoms, with the action of an aqueous acid.
公开/授权文献
- US5999757A Sheet transportation device 公开/授权日:1999-12-07