发明授权
US4169140A Antibiotics SF-1771 substance and SF-1771-B substance as well as the
production of these substances
失效
抗生素SF-1771物质和SF-1771-B物质以及这些物质的生产
- 专利标题: Antibiotics SF-1771 substance and SF-1771-B substance as well as the production of these substances
- 专利标题(中): 抗生素SF-1771物质和SF-1771-B物质以及这些物质的生产
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申请号: US736143申请日: 1976-10-27
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公开(公告)号: US4169140A公开(公告)日: 1979-09-25
- 发明人: Kazunori Ohba , Takashi Shomura , Hiroshi Watanabe , Kunikazu Totsukawa , Michio Kojima , Shoji Omoto , Takashi Tsuruoka , Shigeharu Inoue , Taro Niida
- 申请人: Kazunori Ohba , Takashi Shomura , Hiroshi Watanabe , Kunikazu Totsukawa , Michio Kojima , Shoji Omoto , Takashi Tsuruoka , Shigeharu Inoue , Taro Niida
- 申请人地址: JPX Kyobashi
- 专利权人: Meiji Seika Kaisha, Ltd.
- 当前专利权人: Meiji Seika Kaisha, Ltd.
- 当前专利权人地址: JPX Kyobashi
- 优先权: JPX50-129306 19751029
- 主分类号: A61K35/74
- IPC分类号: A61K35/74 ; A61P31/04 ; C07G11/00 ; C12P1/06 ; C12R1/465 ; A61K35/00
摘要:
A new antibiotic SF-1771 substance is produced by cultivating a new strain, Streptomyces toyocaensis SF-1771, in a liquid culture medium under aerobic conditions. This antibiotic may be isolated from the fermentation broth by treating the broth filtrate with a synthetic adsorbent resin for adsorption of the active compound and eluting the resin with an aqueous alcohol or aqueous acetone, followed by chromatographic purification. SF-1771 substance is a copper-containing antibiotic which shows antibacterial activity against Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Removal of the copper component from SF-1771 substance by treatment with hydrogen sulfide, an alkali metal sulfide or a copper-chelating agent gives SF-1771-B substance containing no copper component which shows antibacterial activity as high as but a toxicity lower than SF-1771 substance.
公开/授权文献
- US5304378A Wound dressing material 公开/授权日:1994-04-19