发明授权
- 专利标题： Novel morpholine derivatives and treating depression therewith
- 专利标题（中）： 新型吗啉衍生物和治疗抑郁症
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申请号： US811944申请日： 1977-06-30
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公开(公告)号： US4169146A公开(公告)日： 1979-09-25
- 发明人: Junki Katsube , Atsuyuki Kojima , Makoto Sunagawa , Yoshinori Takashima , Yoshito Kameno , Hisao Yamamoto
- 申请人： Junki Katsube , Atsuyuki Kojima , Makoto Sunagawa , Yoshinori Takashima , Yoshito Kameno , Hisao Yamamoto
- 申请人地址： JPX Osaka
- 专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人地址： JPX Osaka
- 优先权： JPX50-4540 19750601; JPX50-67767 19750604
- 主分类号： C07D265/30
- IPC分类号： C07D265/30 ; C07D267/10 ; A61K27/00
摘要：
Novel morpholine compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, aryl-(C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.4)alkyl, polyhalo(C.sub.2 -C.sub.4) alkyl or hydroxy(C.sub.2 -C.sub.4)alkyl, A represents straight or branched C.sub.2 -C.sub.4 alkylene, B represents a divalent radical selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 --O--, --CH.sub.2 --S--, --S-- and --O--, >D--E-- represents a trivalent radical selected from the group consisting of >CH--CH.sub.2 -- and >C.dbd.CH-- and C.sub.1 and C.sub.2 each represent 1,2-phenylene optionally substituted with one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, and their non-toxic salts, which are useful as antidepressants and can be produced by various methods.
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