A nuclear reactor containment arrangement incorporating a permanent cavity to vessel seal in the form of a flexible quarter-circular annular steel gasket affixed to and extending between the reactor vessel seal plate and cavity wall. The seal functions to isolate the periphery of the vessel from a permanent water-tight compartment above the reactor vessel which is flooded during refueling operations to minimize the release of radiation upon exposure of the nuclear core. The seal is designed to accommodate both radial and axial expansion of the pressure vessel relative to the cavity wall occurring during reactor operation without breaking the water-tight integrity of the seal. The pressure vessel ventilation system is provided with an air exit duct at the reactor nozzle level to facilitate the circulation of air around the periphery of the vessel which would otherwise be restricted at the seal to vessel interface.