发明授权
- 专利标题: 3-Nitropyrazole compounds and anti-microbial compositions
- 专利标题(中): 3-硝基吡唑化合物和抗微生物组合物
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申请号: US889594申请日: 1978-03-23
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公开(公告)号: US4172136A公开(公告)日: 1979-10-23
- 发明人: Herbert Berger , Rudi Gall , Kurt Stach, deceased , Max Thiel , Wolfgang Vomel
- 申请人: Herbert Berger , Rudi Gall , Kurt Stach, deceased , Max Thiel , Wolfgang Vomel
- 申请人地址: DEX Mannheim
- 专利权人: Boehringer Mannheim GmbH
- 当前专利权人: Boehringer Mannheim GmbH
- 当前专利权人地址: DEX Mannheim
- 优先权: DEX2558117 19751223
- 主分类号: C07D231/16
- IPC分类号: C07D231/16 ; C07D401/02 ; C07D403/02
摘要:
New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is cyano, carboxyl or lower alkoxycarbonyl or the radical --CO-NR.sub.4 R.sub.5, in whichR.sub.4 is hydrogen or hydroxyl, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, thiocarbamoyl, ureido, thioureido, hydroxyphenyl, picolyl or is a lower alkyl, alkenyl or cycloalkyl radical substituted, if desired, by a cyano, hydroxyl, pyrrolidino, piperidino, amino, lower alkylamino, lower dialkylamino or lower acylamino substituent andR.sub.5 is a hydrogen atom or a lower alkyl radical orR.sub.4 and R.sub.5 together represent a lower alkylene bridge;And the pharmacologically compatible salts thereof are outstandingly effective as anti-microbial agents, particularly systemically and in the urinary tract.