发明授权
- 专利标题: Certain nicotinamido-n-benzoic acid derivatives
- 专利标题(中): 某些烟酰氨基 - 正苯甲酸衍生物
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申请号: US878602申请日: 1978-02-16
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公开(公告)号: US4181658A公开(公告)日: 1980-01-01
- 发明人: Volker Hitzel , Rudi Weyer , Karl Geisen , Werner Pfaff
- 申请人: Volker Hitzel , Rudi Weyer , Karl Geisen , Werner Pfaff
- 申请人地址: DEX Frankfurt am Main
- 专利权人: Hoechst Aktiengesellschaft
- 当前专利权人: Hoechst Aktiengesellschaft
- 当前专利权人地址: DEX Frankfurt am Main
- 优先权: DEX2706977 19770218
- 主分类号: C07D213/81
- IPC分类号: C07D213/81 ; C07D213/80 ; C07D213/82 ; C07D213/56 ; A61K31/44
摘要:
Benzoic acid derivatives of the formula ##STR1## wherein T is hydrogen or halogen, W is a carboxyl group, an ester or salt thereof; X is ##STR2## wherein R.sub.1 is alkyl having from 2 to 8 carbon atoms, aralkyl or phenyl, cycloalkyl, cycloalkylalkyl or alkylcycloalkyl; R.sub.2 is hydrogen or halogen, R.sub.3 is alkyl having from 5 to 8 carbon atoms, aralkyl or phenyl, or cycloalkyl having from 5 to 8 carbon atoms; R.sub.4 is hydrogen or alkyl; Y is a single chemical bond or a hydrocarbon chain having from 1 to 3 carbon atoms; and Z is hydrogen, halogen, alkyl, alkoxy, alkoxyalkoxy or alkenyloxy, have a blood sugar lowering effect and can be used for the treatment of Diabetes mellitus.
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