发明授权
- 专利标题： Process for the production of 3-aminoisoxazoles
- 专利标题（中）： 生产3-氨基异恶唑的方法
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申请号： US912252申请日： 1978-06-05
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公开(公告)号： US4200757A公开(公告)日： 1980-04-29
- 发明人: Yasuo Makisumi , Akira Murabayashi , Takashi Sasatani
- 申请人： Yasuo Makisumi , Akira Murabayashi , Takashi Sasatani
- 申请人地址： JPX Osaka
- 专利权人： Shionogi & Co., Ltd.
- 当前专利权人： Shionogi & Co., Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX52-68173 19770608
- 主分类号： C07D261/14
- IPC分类号： C07D261/14 ; C07D261/08
摘要：
3-Aminoisoxazoles of the formula: ##STR1## (wherein R is C.sub.1 -C.sub.6 alkyl, phenyl or halo-phenyl) are prepared by reacting a .beta.-ketonitrile of the formula:R--CO--CH.sub.2 CN(wherein R is as defined above) with a compound of the formula:HY(wherein Y is C.sub.1 -C.sub.6 alkoxy or C.sub.1 -C.sub.6 alkylthio) in the presence of an acid in a solvent to give an iminium salt of the formula: ##STR2## (wherein X is the residue of said acid; R and Y are each as defined above) and further reacting the iminium salt with hydroxylamine in an inert solvent.
公开/授权文献
- US5950873A Dental product 公开/授权日：1999-09-14