发明授权
US4201784A Substituted 2-[2'-(5"-nitrofuryl-2")vinyl-and
4'-(5"-nitrofuryl-2"-1,3-butadieryl]quinoline-4-carboxylic acid amides
and salts thereof
失效
取代的2- [2' - （5“ - 硝基呋喃基-2”）乙烯基和4' - （5“ - 硝基呋喃基-2”-1,3-丁二烯基]喹啉-4-羧酸酰胺和盐 其中
- 专利标题： Substituted 2-[2'-(5"-nitrofuryl-2")vinyl-and 4'-(5"-nitrofuryl-2"-1,3-butadieryl]quinoline-4-carboxylic acid amides and salts thereof
- 专利标题（中）： 取代的2- [2' - （5“ - 硝基呋喃基-2”）乙烯基和4' - （5“ - 硝基呋喃基-2”-1,3-丁二烯基]喹啉-4-羧酸酰胺和盐 其中
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申请号： US940798申请日： 1978-09-07
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公开(公告)号： US4201784A公开(公告)日： 1980-05-06
- 发明人: Nina M. Sukhova , Marger J. Lidaka , Valentina A. Voronova , Aina A. Zidermane , Iya M. Kravchenko , Anda Z. Dauvarte , Ieva E. Preisa , Dainuvite V. Meirena
- 申请人： Nina M. Sukhova , Marger J. Lidaka , Valentina A. Voronova , Aina A. Zidermane , Iya M. Kravchenko , Anda Z. Dauvarte , Ieva E. Preisa , Dainuvite V. Meirena
- 申请人地址： SUX Riga
- 专利权人： Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi SSR
- 当前专利权人： Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi SSR
- 当前专利权人地址： SUX Riga
- 优先权： SUX2524871 19770909
- 主分类号： C07D405/06
- IPC分类号： C07D405/06 ; A61K31/345 ; A61K31/44 ; A61K31/443 ; A61K31/47 ; A61K31/4709 ; A61P35/00 ; C07D401/06
摘要：
New compounds of the nitrofuran series are provided, having the following general base formula: ##STR1## where R=CH.sub.2 CH.sub.2 CH.sub.2 OH; --CH(CH.sub.3)(CH.sub.2).sub.3 N(C.sub.2 H.sub.5).sub.2n=1,2and which may be in the form of salts.These compounds, both in the form of base and salt, exhibit a contact-action antiblastic effect. The advantage of these compounds resides in high selectivity of their action on tumoral cells combined with a germicidal activity.These compounds may be used in the medicine as an active source of antiblastic preparations.
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