发明授权
- 专利标题： Polychalcogen ester of cephem compound, process for preparing the same and method for removing the protective group of the same
- 专利标题（中）： 头孢烯化合物的多元硫酸酯，其制备方法及其除去保护基的方法
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申请号： US898613申请日： 1978-04-21
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公开(公告)号： US4225706A公开(公告)日： 1980-09-30
- 发明人: Shigeo Seki , Ken Nishihata , Satoru Nakabayashi , Toshinori Saito , Hitoshi Ikeda , Nobuo Itoh , Shokichi Nakajima , Shunzo Fukatsu
- 申请人： Shigeo Seki , Ken Nishihata , Satoru Nakabayashi , Toshinori Saito , Hitoshi Ikeda , Nobuo Itoh , Shokichi Nakajima , Shunzo Fukatsu
- 申请人地址： JPX Tokyo
- 专利权人： Meiji Seika Kaisha Ltd.
- 当前专利权人： Meiji Seika Kaisha Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX52-50688 19770504; JPX52-50689 19770504; JPX52-103562 19770831
- 主分类号： A61K
- IPC分类号： A61K20060101 ; C07D501/04 ; C07D501/20 ; C07D501/22 ; C07D501/26 ; C07D501/34
摘要：
A novel ester of a cephem compound having a carboxyl group at the 4-position in the nucleus; a process for preparing the same by reacting a cephem carboxylic acid or its salt with a halogenide; and a method for removing the protective group for the carboxyl group in the nucleus of a cephem compound by contacting it with an alcohol, or with an organic solvent in the presence of a Lewis acid.
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