发明授权
- 专利标题: Esters of indole-1-acetic acid and analgesic use thereof
- 专利标题(中): 吲哚-1-乙酸的酯及其止痛用途
-
申请号: US904328申请日: 1978-05-09
-
公开(公告)号: US4233312A公开(公告)日: 1980-11-11
- 发明人: Andre Allais , Jean Meier , Roger Deraedt
- 申请人: Andre Allais , Jean Meier , Roger Deraedt
- 申请人地址: FRX Paris
- 专利权人: Roussel Uclaf
- 当前专利权人: Roussel Uclaf
- 当前专利权人地址: FRX Paris
- 主分类号: C07D209/12
- IPC分类号: C07D209/12 ; A61K31/40 ; C07D209/20
摘要:
Novel indoles of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, halogen, --CF.sub.3, alkyl of 1 to 8 carbon atoms and alkoxy of 1 to 8 carbon atoms, R.sub.2 is in the 2, 3 or 4 position and is selected from the group consisting of halogen, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 8 carbon atoms, A is selected from the group consisting of branched alkylene of 3 to 5 carbon atoms and --(CH.sub.2).sub.n -- and n is a number of 2 to 5 and R.sub.3 and R.sub.4 are alkyl of 1 to 8 carbon atoms or taken together with the nitrogen atom form a heterocyclic ring selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, piperazinyl and N-alkyl piperazinyl with 1 to 4 alkyl carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having analgesic activity and their preparation.
公开/授权文献
信息查询