发明授权
- 专利标题: Bis-isoquinolinium compounds, compositions and methods of use
- 专利标题(中): 双异喹啉鎓化合物,组合物和使用方法
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申请号: US7952申请日: 1979-01-31
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公开(公告)号: US4235906A公开(公告)日: 1980-11-25
- 发明人: John J. Savarese , Richard J. Kitz , Sara Ginsburg
- 申请人: John J. Savarese , Richard J. Kitz , Sara Ginsburg
- 申请人地址: MA Boston
- 专利权人: Massachusetts General Hospital
- 当前专利权人: Massachusetts General Hospital
- 当前专利权人地址: MA Boston
- 主分类号: C07C51/41
- IPC分类号: C07C51/41 ; C07D217/10 ; C07D217/20 ; C07F1/00 ; A61K31/47
摘要:
Intermediate-duration reversible neuromuscular blocking agents of the formula (I) ##STR1## where B and C are preferably para or may be meta and are each ##STR2## where W is CH.sub.2 or most preferably CH.dbd.CH R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are each hydrogen or lower alkoxy of 1 to 4 carbon atoms and preferably methoxy, Y is lower alkyl of 1 to 4 carbon atoms and preferably methyl, Z is hydrogen, lower alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, benzyl, or ##STR3## where ALKYL has 1 to 4 carbon atoms preferably where the O-ALKYL is at the 2, 3, 4 or 5 positions such as 4-methoxy benzyl and is most preferably 3,4-dimethoxy benzyl or 3, 4, 5-trimethoxybenzyl, n is 2, 3 or 4, most preferably 2 or 3 provided that at least one of R.sub.1 to R.sub.4 is lower alkoxy and most preferably where R.sub.1 and R.sub.4 is hydrogen and R.sub.2 and R.sub.3 are methoxy and X is a pharmaceutically acceptable anion.The neuromuscular blocking agents of formula I are useful for administration to a patient to cause skeletal muscle relaxation during surgery and are normally administered intravenously in a pharmaceutically acceptable carrier.
公开/授权文献
- US6080069A Golf club head with improved weight distributions 公开/授权日:2000-06-27
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