A safety closure and container combination is disclosed. The container and closure each have mating lugs which cooperate with each other to move the closure toward the container when rotated in a first direction and to move the closure away from the container when moved in a second direction. Cooperating stop surfaces are provided on the closure and container which engage when the closure is rotated in a direction to move it away from the container so that it is necessary to move the closure toward the container to allow the stop surfaces to move past each other thereby allowing the closure to be removed from the container.