发明授权
US4285950A 10-halo-E-homoeburnane derivatives, a process for the preparation
thereof, a process for the use thereof as vasodilators, and
vasodilating compositions thereof
失效
10-卤代-E-高聚乙二醇衍生物，其制备方法，其用作血管扩张剂的方法及其血管舒张组合物
- 专利标题： 10-halo-E-homoeburnane derivatives, a process for the preparation thereof, a process for the use thereof as vasodilators, and vasodilating compositions thereof
- 专利标题（中）： 10-卤代-E-高聚乙二醇衍生物，其制备方法，其用作血管扩张剂的方法及其血管舒张组合物
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申请号： US175383申请日： 1980-08-05
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公开(公告)号： US4285950A公开(公告)日： 1981-08-25
- 发明人: Csaba Szantay , Lajos Szabo , Gyorgy Kalaus , Lajos Dancsi , Tibor Keve , Ferenc Drexler
- 申请人： Csaba Szantay , Lajos Szabo , Gyorgy Kalaus , Lajos Dancsi , Tibor Keve , Ferenc Drexler
- 申请人地址： HUX Budapest
- 专利权人： Richter Gedeon Vegyeszeti Gyar Rt
- 当前专利权人： Richter Gedeon Vegyeszeti Gyar Rt
- 当前专利权人地址： HUX Budapest
- 优先权： HUXRI723 19790813
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A61P9/08 ; A61P9/10 ; C07D461/00 ; C07D471/22 ; A61K31/395
摘要：
The invention relates to new 10-halo-E-homoeburnane derivatives of the general formula (I), ##STR1## wherein R.sup.2 is a C.sub.1-6 alkyl group and X is halogen, and epimers, optically active derivatives and pharmaceutically acceptable acid addition salts thereof. These substances exert vasodilating effects and can be applied to advantage in the therapy.The new compounds are prepared so that a racemic or optically active 9-halo-octahydroindoloquinolisine derivative of the general formula (II), ##STR2## wherein R.sup.2 and X are as defined above and R.sup.1 is a C.sub.1-6 alkyl group, or an acid addition salt thereof is treated with a strong base, and, if desired, the 15-epimers of the resulting compound having the general formula (I) are separated from each other, and/or, if desired, the resulting substance is converted into its pharmaceutically acceptable acid addition salt and/or resolved.
公开/授权文献
- US5432195A Benzofuran derivative and pharmaceutical composition 公开/授权日：1995-07-11
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