发明授权
- 专利标题: Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives
- 专利标题(中): 反应性青霉烷酸和头孢烷酸衍生物的制备方法
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申请号: US36756申请日: 1979-05-07
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公开(公告)号: US4304717A公开(公告)日: 1981-12-08
- 发明人: Magda Huhn , Gabor Szabo , Gabor Resofszki , Eva Somfai
- 申请人: Magda Huhn , Gabor Szabo , Gabor Resofszki , Eva Somfai
- 申请人地址: HUX Budapest
- 专利权人: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt
- 当前专利权人: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt
- 当前专利权人地址: HUX Budapest
- 优先权: HUXCI1499 19740730
- 主分类号: C07C69/353
- IPC分类号: C07C69/353 ; A61K31/43 ; A61K31/545 ; A61K31/546 ; A61P31/04 ; C07D333/24 ; C07D499/00 ; C07D499/12 ; C07D499/72 ; C07D501/06 ; C07D501/20 ; C07D501/22 ; C07D501/26 ; C07D501/28 ; C07D501/32 ; C07D501/34 ; C07D501/60
摘要:
This invention relates to a process for the preparation of acid amides having the formula (I) or their salts ##STR1## wherein R.sup.1 is hydrogen or an easily removable ester-forming or salt-forming group, preferably a trialkylamine, trialkylsilyl, trichloroethyl, acetoxymethyl, phenacyl, substituted phenacyl, substituted phenyl or benzyl group,R.sup.2 is hydrogen, alkyl group, alkenyl group, alkyl group having an aryl or heterocyclic (preferably furyl or thienyl) - substituent, an aryl group having an alkyl substituent (preferably xylyl), or an aryl, aralkyl or heterocyclic group (preferably a phenyl, thienyl, or furyl group) which can have one or more substituents,R.sup.3 is hydrogen, or substituted or unsubstituted aryl, alkyl, cycloalkyl or aralkyl group, andX is a group of one of the formulae ##STR2## according to the invention an amine of the formula (II), ##STR3## wherein R.sup.4 is an easily removable ester-forming group, preferably a trialkylamino, trialkylsilyl, trichloroethyl, acetoxymethyl, phenacyl, substituted phenacyl, substituted phenyl or benzyl group, or a salt formed preferably with an alkali metal or a trialkylamine, is acylated with an ester of the formula (III), ##STR4## wherein R.sup.5 is a substituted or unsubstituted aryl, alkyl, cycloalkyl or aralkyl group, and, if desired, substituents R.sup.4 and/or R.sup.5 of the obtained product can be split off, and/or, if desired, the obtained product is converted into its salt or a salt is converted into the free acid.
公开/授权文献
- USD368370S Briefcase 公开/授权日:1996-04-02
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