发明授权
- 专利标题: 6,9-Nitrilo-prostaglandin analogues
- 专利标题(中): 6,9-Nitrilo-prostaglandin类似物
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申请号: US122704申请日: 1980-02-19
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公开(公告)号: US4313954A公开(公告)日: 1982-02-02
- 发明人: Hirohisa Wakatsuka , Masaki Hayashi , Yoshitaka Konishi
- 申请人: Hirohisa Wakatsuka , Masaki Hayashi , Yoshitaka Konishi
- 申请人地址: JPX Osaka
- 专利权人: Ono Pharmaceutical Co. Ltd.
- 当前专利权人: Ono Pharmaceutical Co. Ltd.
- 当前专利权人地址: JPX Osaka
- 优先权: JPX54-17935 19790220
- 主分类号: A61K31/557
- IPC分类号: A61K31/557 ; A61P7/02 ; A61P43/00 ; C07C405/00 ; C07D209/52 ; A61K31/40
摘要:
Prostaglandin I.sub.2 analogues of the general formula ##STR1## [wherein R.sup.1 represents a hydrogen atom, an alkyl group containing from 1 to 12 carbon atoms, an aralkyl group containing from 7 to 13 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms unsubstituted or substituted by at least one alkyl group containing from 1 to 4 carbon atoms, a phenyl group unsubstituted or substituted by at least one halogen atom, trifluoromethyl or phenyl group, or by at least one alkyl, alkoxy or alkylthio group containing from 1 to 4 carbon atoms, or represents a group --C.sub.m H.sub.2m COOR.sup.6, --C.sub.n H.sub.2n OR.sup.7 or ##STR2## in which m represents an integer of 1 to 12, n represents an integer of 2 to 12, R.sup.6, R.sup.8 and R.sup.9, which may be the same or different, each represent an alkyl group containing from 1 to 4 carbon atoms, and R.sup.7 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, R.sup.2 represents a hydrogen atom or a methyl or ethyl group, R.sup.3 represents an alkyl group containing from 1 to 4 carbon atoms, R.sup.4 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, R.sup.5 represents an alkyl group containing from 1 to 10 carbon atoms, Y represents ethylene or trans-vinylene, the hydroxy group attached to the C-11 carbon atom is in .alpha.-configuration, and the wavy line attached to the C-15 carbon atom is in .alpha.- or .beta.-configuration or a mixture thereof] and non-toxic acid addition salts thereof and, when R.sup.1 represents a hydrogen atom, non-toxic salts thereof are new compounds possessing pharmacological properties typical of the prostaglandins.
公开/授权文献
- US6007996A In situ method of analyzing cells 公开/授权日:1999-12-28