发明授权
- 专利标题： Maytansinoids, their use and pharmaceutical compositions thereof
- 专利标题（中）： 美登木素类，它们的用途和药物组合物
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申请号： US152392申请日： 1980-05-22
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公开(公告)号： US4317821A公开(公告)日： 1982-03-02
- 发明人: Osamu Miyashita , Hiroshi Akimoto
- 申请人： Osamu Miyashita , Hiroshi Akimoto
- 申请人地址： JPX Osaka
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX54/72811 19790608
- 主分类号： A61K31/535
- IPC分类号： A61K31/535 ; A61P35/00 ; C07D498/18
摘要：
Novel maytansinoids of the formula: ##STR1## wherein Y is H or Cl, and R is C.sub.2-15 alkyl, phenyl-C.sub.1-4 alkyl, pyridyl-C.sub.1-4 alkyl, imidazolyl-C.sub.1-4 alkyl, indolyl-C.sub.1-4 alkyl, furyl-C.sub.1-4 alkyl or thienyl-C.sub.1-4 alkyl, said R group being substituted by hydroxyl, halogen or C.sub.1-5 alkanoyloxy at its .alpha.- and/or .beta.-position, have antimitotic, antitumor and antimicrobial activities.
公开/授权文献
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