发明授权
- 专利标题: 2-Carbamoyloxymethyl-penicillin derivatives
- 专利标题(中): 2-羧甲氧基甲基 - 青霉素衍生物
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申请号: US893092申请日: 1978-04-03
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公开(公告)号: US4322347A公开(公告)日: 1982-03-30
- 发明人: Robert L. Cundall , Derek Walker
- 申请人: Robert L. Cundall , Derek Walker
- 申请人地址: NY New York
- 专利权人: Bristol-Myers Company
- 当前专利权人: Bristol-Myers Company
- 当前专利权人地址: NY New York
- 主分类号: A61K31/43
- IPC分类号: A61K31/43 ; A61K31/545 ; A61K31/546 ; A61P31/04 ; C07D499/00 ; C07D499/21 ; C07D499/42 ; C07D499/44 ; C07D499/46 ; C07D499/60 ; C07D499/64 ; C07D499/68 ; C07D499/74 ; C07D499/76 ; C07D499/78 ; C07D499/80 ; C07D501/14 ; C07D501/18 ; C07D501/22 ; C07D501/59 ; C07D519/06 ; C07D499/32 ; A61K31/38
摘要:
Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.