发明授权
- 专利标题: Process for the production of a 7-methoxycephalosporine derivative
- 专利标题(中): 生产7-甲氧基头孢菌素衍生物的方法
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申请号: US178604申请日: 1980-08-15
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公开(公告)号: US4324891A公开(公告)日: 1982-04-13
- 发明人: Katsuyoshi Iwamatsu , Takashi Tsuruoka , Kazuko Mizutani , Katsumi Kawaharajyo , Tadahiro Watanabe , Shigeharu Inouye
- 申请人: Katsuyoshi Iwamatsu , Takashi Tsuruoka , Kazuko Mizutani , Katsumi Kawaharajyo , Tadahiro Watanabe , Shigeharu Inouye
- 申请人地址: JPX Tokyo
- 专利权人: Meiji Seika Kaisha, Ltd.
- 当前专利权人: Meiji Seika Kaisha, Ltd.
- 当前专利权人地址: JPX Tokyo
- 主分类号: C07D501/04
- IPC分类号: C07D501/04 ; C07D501/57
摘要:
A new, efficient process is provided for the production of 7.beta.-[(2D-2-amino-2-carboxy)-ethylthio-acetamido]-7.alpha.-methoxy-3-[(1-methyl-1H-tetrazole-5-yl) thiomethyl]-3-cephem-4-carboxylic acid useful as new antibacterial agent. This process is economic in using as the starting material the inexpensive, corresponding cephem compound containing no 7.alpha.-methoxy group on the cephem nucleus and comprises 7.alpha.-methoxylation of a protected derivative of the starting cephem compound with t-butyl hypochlorite and lithium methoxide, followed by inactivation of the excessive methoxylation reagents with a trialkyl phosphite and acetic acid to prevent undesired side-reactions such as oxidation of the alkylthioacetyl group of the product, and further by conventional removal of the protecting groups.
公开/授权文献
- US6126729A Portable air filter system 公开/授权日:2000-10-03