发明授权
- 专利标题: 3,4-Diarylisoxazol-5-acetic acids and process for making same
- 专利标题(中): 3,4-二芳基异恶唑-5-乙酸及其制备方法
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申请号: US190060申请日: 1980-09-23
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公开(公告)号: US4327222A公开(公告)日: 1982-04-27
- 发明人: Ronald G. Micetich , Chia-Cheng Shaw , Ram B. Rastogi
- 申请人: Ronald G. Micetich , Chia-Cheng Shaw , Ram B. Rastogi
- 申请人地址: CAX Toronto
- 专利权人: CDC Life Sciences Inc.
- 当前专利权人: CDC Life Sciences Inc.
- 当前专利权人地址: CAX Toronto
- 优先权: CAX337097 19791005
- 主分类号: A61K31/42
- IPC分类号: A61K31/42 ; A61P25/04 ; A61P29/00 ; C07D261/08
摘要:
3,4-Diarylisoxazol-5-acetic acids of the formula ##STR1## in which Ar.sup.1 and Ar.sup.2 are the same or different and are selected from phenyl and naphthyl, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are the same or different and are selected from hydrogen, halogen, trifluoromethyl, lower alkyl, and lower alkoxy, and R.sup.5 is selected from hydrogen, lower alkyl, and lower alkoxy. The compounds have anti-inflammatory, analgesic, and anti-pyretic activities and a low order of toxicity, and methods for their preparation and use are also disclosed.