发明授权
- 专利标题： Cyclization to form cephem ring and intermediates therefor
- 专利标题（中）： 环化形成头孢烯环及其中间体
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申请号： US125232申请日： 1980-02-27
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公开(公告)号： US4332722A公开(公告)日： 1982-06-01
- 发明人: Teruji Tsuji , Yoshio Hamashima , Mitsuru Yoshioka , Masayuki Narisada , Hiroshi Tanida , Taichiro Komeno , Wataru Nagata
- 申请人： Teruji Tsuji , Yoshio Hamashima , Mitsuru Yoshioka , Masayuki Narisada , Hiroshi Tanida , Taichiro Komeno , Wataru Nagata
- 申请人地址： JPX Osaka
- 专利权人： Shionogi & Co., Ltd.
- 当前专利权人： Shionogi & Co., Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX50-19612 19750217; JPX50-22229 19750221; JPX50-28452 19750307; JPX50-33808 19750330
- 主分类号： C07D205/095
- IPC分类号： C07D205/095 ; C07D501/08 ; C07D487/04
摘要：
An intermediate represented by the following formula, for synthesizing --3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy protecting group; the broken line between A and R shows that when R and B are hydrogens, and A is a carboxylic acyl, the substituents can be combined to form an azetidinothiazoline bicyclic ring; and the enamine derivatives thereof.