发明授权
US4340727A 1,2-Modified fortimicins A and B, intermediates therefor and method for
their manufacture
失效
1,2-改性的fortimicins A和B，其中间体及其制备方法
- 专利标题： 1,2-Modified fortimicins A and B, intermediates therefor and method for their manufacture
- 专利标题（中）： 1,2-改性的fortimicins A和B，其中间体及其制备方法
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申请号： US201651申请日： 1980-10-28
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公开(公告)号： US4340727A公开(公告)日： 1982-07-20
- 发明人: Jerry R. Martin , John S. Tadanier , Paulette Johnson
- 申请人： Jerry R. Martin , John S. Tadanier , Paulette Johnson
- 申请人地址： IL North Chicago
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： IL North Chicago
- 主分类号： C07H15/224
- IPC分类号： C07H15/224 ; C07H15/22
摘要：
A 1,2-modified fortimicin A or B represented by the formulae I, II and III: ##STR1## wherein R is hydrogen or loweralkyl; and R.sub.1 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-lower-alkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, amino hydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N-N-diloweralkylaminohydroxyloweralkyl, acyl, aminoacyl, hydroxy-substituted aminoacyl, diaminoacyl, hydroxyacyl, hydroxy-substituted diaminoacyl, N-loweralkylaminoacyl, N, N-diloweralkylaminoacyl, hydroxysubstituted-N-loweralkylaminoacyl and hydroxy-substituted-N, N-diloweralkylaminoacyl, and the pharmaceutically acceptable salts thereof. The compounds are broad spectrum antibiotics.