发明授权
US4341790A Pyrrolidinylalkylcarboxylic acid amide derivatives, their preparation
and pharmaceutical compositions containing them
失效
吡咯烷基烷基羧酸酰胺衍生物,其制备方法和含有它们的药物组合物
- 专利标题: Pyrrolidinylalkylcarboxylic acid amide derivatives, their preparation and pharmaceutical compositions containing them
- 专利标题(中): 吡咯烷基烷基羧酸酰胺衍生物,其制备方法和含有它们的药物组合物
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申请号: US155952申请日: 1980-06-03
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公开(公告)号: US4341790A公开(公告)日: 1982-07-27
- 发明人: Hans Betzing , Jurgen Biedermann , Carsten Materne , Volker Neuser
- 申请人: Hans Betzing , Jurgen Biedermann , Carsten Materne , Volker Neuser
- 申请人地址: DEX
- 专利权人: A. Nattermann & Cie. GmbH
- 当前专利权人: A. Nattermann & Cie. GmbH
- 当前专利权人地址: DEX
- 优先权: DEX2923975 19790613; DEX2924011 19790613
- 主分类号: C07D207/26
- IPC分类号: C07D207/26 ; C07D207/27 ; C07D207/273 ; A61K31/40 ; A61K31/44
摘要:
2-Oxo-1-pyrrolidinylalkylcarboxylic acid amides of formula I ##STR1## in which R represents a hydrogen atom or hydroxy group, R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents a substituted or unsubstituted pyridyl group or a substituted phenyl group, the substitution being by from 1 to 3 substituents, which may be the same or different selected from halogen atoms, trifluoromethyl, nitro and acetyl groups, straight or branched-chain alkyl groups having 1-4 carbon atoms, alkoxy groups having 1-4 carbon atoms, straight or branched-chain alkylmercapto groups having 1-7 carbon atoms, substituted alkylmercapto groups of the general formula II ##STR2## in which n represents 1 or 2, R.sub.3 is a hydrogen atom or a methyl group and R.sub.4 is a hydroxy group or an amino group of the general formula V ##STR3## in which R.sub.8 represents a hydrogen atom or methyl group and R.sub.9 represents a methyl group or substituted or unsubstituted benzyl group, or R.sub.8 and R.sub.9 together with the nitrogen atom shown in formula V, form a substituted pyrrolidine ring; sulphonyl groups of the general formula III--SO.sub.2 R.sub.5 IIIin which R.sub.5 represents an --NH.sub.2 group or an alkyl group having 1-3 carbon atoms; and aminoethoxycarbonyl groups of the general formula IV ##STR4## in which each of R.sub.6 and R.sub.7, which may be the same or different, represents a hydrogen atom or methyl or ethyl group; and the pharmaceutically tolerable acid addition salts of compounds of formula I having a basic nitrogen atom are useful in treating cerebral circulatory disturbances, cerebro-atrophic crises and cerebral ageing processes.