发明授权
US4348327A Process for the preparation of 17.alpha.-hydroxy- and
17a.alpha.-hydroxy-D-homoetiocarboxylic acids
失效
制备17α-羟基和17aα-羟基-D-高聚羧酸的方法
- 专利标题： Process for the preparation of 17.alpha.-hydroxy- and 17a.alpha.-hydroxy-D-homoetiocarboxylic acids
- 专利标题（中）： 制备17α-羟基和17aα-羟基-D-高聚羧酸的方法
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申请号： US276563申请日： 1981-06-23
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公开(公告)号： US4348327A公开(公告)日： 1982-09-07
- 发明人: Robert Nickolson , Ulrich Kerb , Rudolf Wiechert , Leo Alig , Andor Furst , Marcel Muller
- 申请人： Robert Nickolson , Ulrich Kerb , Rudolf Wiechert , Leo Alig , Andor Furst , Marcel Muller
- 申请人地址： DEX Berlin & Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin & Bergkamen
- 优先权： DEX3024008 19800624
- 主分类号： C07J3/00
- IPC分类号： C07J3/00 ; C07J41/00 ; C07J63/00 ; C07J9/00
摘要：
17.alpha.-hyroxy- and 17a.alpha.-hydroxy-D-homoetiocarboxylic acids of the formula ##STR1## wherein n is 1 or 2,A is ##STR2## and R.sub.1 is H or CH.sub.3are prepared by hydrating the corresponding 17-nitriles with a mixture of a lower carboxylic acid and its anhydride in the presence of perchloric acid. The resultant 17.beta.-N-acylcarboxamide is then treated with an alkali metal hydroxide in a polyhydric alcohol at an elevated temperature. The product acids are intermediates, e.g., for the production of steroids having antiinflammatory activity.