发明授权
US4352753A 3-[[(2,3-Dihydro-1H-indol-2-yl)carbonyl]thio]propanoic (and acetic)
acids as intermediates
失效
3 - [[（2,3-二氢-1H-吲哚-2-基）羰基]硫基]丙酸（和乙酸）为中间体
- 专利标题： 3-[[(2,3-Dihydro-1H-indol-2-yl)carbonyl]thio]propanoic (and acetic) acids as intermediates
- 专利标题（中）： 3 - [[（2,3-二氢-1H-吲哚-2-基）羰基]硫基]丙酸（和乙酸）为中间体
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申请号： US220652申请日： 1980-12-29
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公开(公告)号： US4352753A公开(公告)日： 1982-10-05
- 发明人: Dong H. Kim , Ronald J. McCaully
- 申请人： Dong H. Kim , Ronald J. McCaully
- 申请人地址： NY New York
- 专利权人： American Home Products Corporation
- 当前专利权人： American Home Products Corporation
- 当前专利权人地址： NY New York
- 优先权： ARX282109 19800811
- 主分类号： C07D209/42
- IPC分类号： C07D209/42 ; C07D209/12 ; C07D209/18
摘要：
Disclosed herein are 3[[(2,3-dihydro-1H-indole-2-yl)carbonyl]thio]propanoic (and acetic) acids of the general formula: ##STR1## wherein: n is 1 or 0;R.sub.1 is hydrogen, lower alkyl, aryl, or aralkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is hydrogen, lower alkyl or aroyl;X is hydrogen, hydroxy, lower alkyl, lower alkoxy, or halogen; andY is hydrogen, lower alkyl, or aryl; or salts thereof.These compounds are intermediates for the production of 1H,3H-[1,4]thiazepino[4,3-a]indoles and 1H-[1,4]thiazino[4,3-a]indoles which possess Angiotensin Converting Enzyme inhibition activity and anti-hypertensive activity.
公开/授权文献
- US5460374A Game device 公开/授权日：1995-10-24
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