发明授权
- 专利标题: Process for producing a multi-layered slow release composite
- 专利标题(中): 制备多层缓释复合材料的方法
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申请号: US233135申请日: 1981-02-10
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公开(公告)号: US4359483A公开(公告)日: 1982-11-16
- 发明人: Isao Kaetsu , Masaru Yoshida
- 申请人: Isao Kaetsu , Masaru Yoshida
- 申请人地址: JPX Tokyo
- 专利权人: Japan Atomic Energy Research Institute
- 当前专利权人: Japan Atomic Energy Research Institute
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX55/23878 19800227
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K9/20 ; A61K9/22 ; A61K9/24 ; A61K9/70 ; A01N1/02 ; B05D3/00 ; B05D3/06
摘要:
A process is herein disclosed for producing a multi-layered slow release composite comprising: a first step wherein one or more physiologically active substances is mixed with one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof, and the mixture is given a predetermined shape and subjected to a physical treatment to form a slow release composite; a second step wherein a predetermined thickness of coating of one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof is formed on the surface of said slow release composite, which then is subjected to a physical treatment so that a layer wherein no physiologically active substance is encapsulated is formed on the surface of said slow release composite; a third step wherein a predetermined thickness of coating of a mixture of one or more physiologically active substances with one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof is formed on the surface of the slow release composite having the layer provided in the second step wherein no physiologically active substance is encapsulated, said composite then is subjected to a physical treatment to form a layer wherein the physiologically active substance is encapsulated.