发明授权
US4365064A 1,2,4-Oxadiazolin-5-one derivatives, process for their preparation and
pharmaceutical compositions containing them
失效
1,2,4-恶二唑啉-5-酮衍生物,其制备方法和含有它们的药物组合物
- 专利标题: 1,2,4-Oxadiazolin-5-one derivatives, process for their preparation and pharmaceutical compositions containing them
- 专利标题(中): 1,2,4-恶二唑啉-5-酮衍生物,其制备方法和含有它们的药物组合物
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申请号: US196583申请日: 1980-10-14
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公开(公告)号: US4365064A公开(公告)日: 1982-12-21
- 发明人: Kalman Takacs , Ilona Kiss nee Ajzert , Antal Simay , Peter Literati Nagy , Maria Hetyey nee Papp , Marian Ecsery nee Puskas , Laszlo Szekeres , Gyula Papp , Sandor Viragh , Eva Udvardy
- 申请人: Kalman Takacs , Ilona Kiss nee Ajzert , Antal Simay , Peter Literati Nagy , Maria Hetyey nee Papp , Marian Ecsery nee Puskas , Laszlo Szekeres , Gyula Papp , Sandor Viragh , Eva Udvardy
- 申请人地址: HUX Budapest
- 专利权人: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt
- 当前专利权人: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt
- 当前专利权人地址: HUX Budapest
- 优先权: HUXCI1973 19791011
- 主分类号: C07D413/06
- IPC分类号: C07D413/06 ; A61K20060101 ; A61K31/41 ; A61K31/415 ; A61K31/42 ; A61K31/435 ; A61K31/47 ; A61K31/475 ; A61P9/08 ; C07D20060101 ; C07D217/00 ; C07D217/04 ; C07D217/16 ; C07D271/00 ; C07D271/06 ; C07D273/04 ; C07D401/06
摘要:
The invention concerns new compounds of the formula (I) ##STR1## wherein R.sup.1 is hydrogen, phenyl or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro;R.sup.2 is alkyl having 1 to 4 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, phenyl, or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro;R.sup.3 is alkoxy having 1 to 4 carbon atoms or hydrogen,R.sup.4 is hydrogen, alkyl having 1 to 4 carbon atoms unsubstituted or substituted with alkoxy having 1 to 4 carbon atoms, benzyloxy or cyano, phenyl, or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro, or phenyl-(C.sub.1-4 alkyl)-alkyl, in which the phenyl moiety may bear an alkoxy substituent having 1 to 4 carbon atoms or a halogen;m and n are each 0, 1 or 2 or a pharmaceutically acceptable acid addition or quaternary salt thereof.The compounds are potent vasodilators and exert a favorable influence on the extremital blood flow. They also show a heart function influencing activity.Methods for the preparation of said compounds and pharmaceutical compositions containing them are also the subject of the invention.