A mouth cleaning device of this invention comprises a hand held gripping part with brush and nozzle members selectively mounted thereto. The gripping part is provided with a driving rod for transmitting to the selectively mounted brush member a reciprocal turning force and for providing to the selectively mounted nozzle member a water feeding path to lead water to the nozzle member from an external water feeding means. A driving means provides a reciprocal turning force to the driving rod. A change-over switch drives the driving means only when the brush member is mounted so that, when the brush member is mounted to the gripping part, the brush member will be reciprocally turned to perform tooth brushing. When the nozzle member is mounted to the gripping part, water will be jetted out of the nozzle member to perform gum cleaning and massaging.