发明授权
- 专利标题: Antisecretory imidazole amidine compounds, composition and method of use
- 专利标题(中): 咪唑咪唑类化合物,组成及使用方法
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申请号: US193742申请日: 1980-10-03
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公开(公告)号: US4379158A公开(公告)日: 1983-04-05
- 发明人: Yasufumi Hirata , Isao Yanagisawa , Toshinari Tamura , Masaaki Takeda
- 申请人: Yasufumi Hirata , Isao Yanagisawa , Toshinari Tamura , Masaaki Takeda
- 申请人地址: JPX Tokyo
- 专利权人: Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人: Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX52-104079 19770829; JPX53-86944 19780717
- 主分类号: C07D213/32
- IPC分类号: C07D213/32 ; C07D213/68 ; C07D213/86 ; C07D233/54 ; C07D233/64 ; C07D277/26 ; C07D277/30 ; C07D307/52 ; A61K31/615 ; C07D401/12
摘要:
Novel heterocyclic compounds shown by the formula ##STR1## wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen atom; X represents an oxygen atom or the unsubstituted or substituted imino group shown by N--R.sub.1 (wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a cyano group, an unsubstituted or alkyl substituted carbamoyl group, an unsubstituted or lower alkyl substituted thiocarbamoyl group, or a lower alkanoylamino group); Y represents a hydrogen atom, a lower alkyl group which may have substituent(s), a cycloalkyl group of 3-6 carbon atoms, a lower alkenyl group, a lower alkynyl group, an aryl group which may have substituent(s), an aralkyl group which may have substituent(s), a hydroxyl group, a cyano group, a carbamoyl group, an amidino group, an alkanoyl group which may have been substituted by halogen atom(s), an alkanoylamino group, an arylcarbonylamino group, an alkylamino group, an arylamino group, an arylsulfamoyl group, a lower alkoxycarbamoyl group, or an oxamoylamino group; and m and n represent an integer of 1-3; when X is N--R.sub.1, said X and Y may combine with each other to form a 5-membered or 6-membered heterocyclic ring containing 2-3 nitrogen atoms which may have substituent(s), and the pharmacologically acceptable acid addition salts thereof.The compounds of this invention are useful as gastric acid secretion inhibitors.
公开/授权文献
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