发明授权
- 专利标题: 2-Phenyl-pyrimidones
- 专利标题(中): 2-苯基 - 嘧啶酮
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申请号: US327348申请日: 1981-12-04
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公开(公告)号: US4379788A公开(公告)日: 1983-04-12
- 发明人: Joachim Heider , Volkhard Austel , Wolfgang Eberlein , Rudolf Kadatz , Christian Lillie
- 申请人: Joachim Heider , Volkhard Austel , Wolfgang Eberlein , Rudolf Kadatz , Christian Lillie
- 申请人地址: DEX Biberach an der Riss
- 专利权人: Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
- 当前专利权人: Dr. Karl Thomae Gesellschaft mit beschrankter Haftung
- 当前专利权人地址: DEX Biberach an der Riss
- 优先权: DEX3046871 19801212; DEX3115447 19810416
- 主分类号: C07D239/88
- IPC分类号: C07D239/88 ; A61K31/513 ; A61P9/00 ; C07D213/82 ; C07D239/91 ; C07D265/22 ; C07D471/04 ; C07D498/04 ; A61K31/505
摘要:
Compounds of the formula ##STR1## wherein A and B, together with each other and the respective carbon atoms to which they are attached, form a phenyl or pyridine ring;R.sub.1 is hydrogen, halogen, amino, nitro, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;R.sub.2 is hydrogen or alkoxy of 1 to 3 carbon atoms;D is alkylene of 3 to 4 carbon atoms or hydroxy(alkylene of 3 to 4 carbon atoms);R.sub.3 and R.sub.5, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is hydrogen or alkoxy of 1 to 3 carbon atoms; andR.sub.6 is straight or branched alkyl of 1 to 6 carbon atoms or --E--R.sub.7 ;where E is straight alkylene of 2 to 4 carbon atoms or hydroxy-substituted straight alkylene of 2 to 4 carbon atoms, andR.sub.7 is ##STR2## where R.sub.8 and R.sub.9 are each hydrogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof formed with inorganic or organic acids; the compounds as well as their salts are useful as hypotensives, antiarrhythmics and .beta.-receptor-blockers.