发明授权
- 专利标题: Process for preparing .alpha.-hydroxyaldehyde
- 专利标题(中): 制备α-羟基醛的方法
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申请号: US257587申请日: 1981-04-27
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公开(公告)号: US4383122A公开(公告)日: 1983-05-10
- 发明人: Teruaki Mukaiyama , Yoji Sakito , Masatoshi Asami
- 申请人: Teruaki Mukaiyama , Yoji Sakito , Masatoshi Asami
- 申请人地址: JPX Osaka
- 专利权人: Sumitomo Chemical Company, Limited
- 当前专利权人: Sumitomo Chemical Company, Limited
- 当前专利权人地址: JPX Osaka
- 优先权: JPX53-135511 19781102; JPX53-137147 19781106; JPX54-70365 19790604; JPX54-70366 19790604; JPX54-70367 19790604
- 主分类号: C07C45/27
- IPC分类号: C07C45/27 ; C07C45/56 ; C07C47/263 ; C07C47/27 ; C07C47/277 ; C07D487/04
摘要:
An optically active or racemic .alpha.-hydroxyaldehyde represented by the general formula (2), ##STR1## wherein R.sub.1 represents a C.sub.6 -C.sub.14 aryl group, C.sub.1 -C.sub.10 alkyl group, C.sub.3 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, or a group containing a functional group in the organic portion of said groups and R.sub.2 represents a C.sub.1 -C.sub.10 alkyl group, C.sub.2 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.6 -C.sub.14 aryl group, or a group containing a functional group in the organic portion of these groups, which is an important intermediate for preparation of pharmaceuticals and agricultural chemicals, and prepared by allowing an optically active or racemic compound represented by the general formula (1), ##STR2## (wherein A represents a C.sub.6 -C.sub.14 aryl group or a C.sub.1 -C.sub.4 alkyl or alkoxy group- or halogen-substituted C.sub.6 -C.sub.14 aryl group and R.sub.1 is as defined above) to react with a Grignard reagent, and thereafter hydrolyzing the reaction product.