A ground station forming part of a system for controlling the flight of a missile comprises two cascaded computers, the first of these computers generating guidance instructions on the basis of initially available data while the second computer converts these instructions into control signals transmitted to the missile. A receiver aboard the missile translates these control signals into operating commands for missile-borne actuators affecting its course, e.g. motors controlling yaw and pitch through the positioning of aerodynamic surfaces; the responses of the actuators to the operating commands are monitored by negative-feedback loops including error-correcting networks.