发明授权
- 专利标题: Process for preparing 2-oxycephalosporin derivatives
- 专利标题(中): 2-羟基头孢菌素衍生物的制备方法
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申请号: US407328申请日: 1982-08-12
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公开(公告)号: US4401528A公开(公告)日: 1983-08-30
- 发明人: Sigeru Torii , Hideo Tanaka , Junzo Nokami , Takashi Shiroi , Norio Saito , Michio Sasaoka
- 申请人: Sigeru Torii , Hideo Tanaka , Junzo Nokami , Takashi Shiroi , Norio Saito , Michio Sasaoka
- 申请人地址: JPX
- 专利权人: Otsuka Kagaku Yakuhin Kabushiki Kaisha
- 当前专利权人: Otsuka Kagaku Yakuhin Kabushiki Kaisha
- 当前专利权人地址: JPX
- 优先权: JPX56-133774 19810825
- 主分类号: C25B3/02
- IPC分类号: C25B3/02 ; A61K31/545 ; C07D501/04 ; C07D501/18 ; C07D501/20 ; C07D501/22 ; C07D501/26 ; C25B3/00 ; C25B3/08
摘要:
This invention provides a process for preparing 2-oxycephalosporin derivative represented by the formula ##STR1## wherein R.sup.1 represents hydrogen atom, acyl group, or lower alkoxycarbonyl group optionally substituted with halogen atom, R.sup.2 represents hydrogen atom, halogen atom or acyloxy group optionally substituted with halogen atom, R.sup.3 represents hydrogen atom, lower alkyl group optionally substituted with halogen atom, or phenyl-lower alkyl group which may be optionally substituted with nitro group, halogen atom or lower alkoxy group on the phenyl ring, and R.sup.4 represents lower primary or secondary alkyl or lower alkylcarbonyl, the process comprising electrolytically oxidizing a cephalosporin derivative represented by the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, in the presence of a lower carboxylic acid or lower primary or secondary alcohol, and a supporting electrolyte.