A needle and syringe destructor is disclosed having particular suitability for the destruction of hypodermic syringe needles, of the single-use variety, immediately after use. The needle, and a portion of the syringe barrel, may be simultaneously severed in a single motion by means of the operator actuating a lever arm means. The lever arm means is linked to a pair of guillotine shears effectuating severance with increased mechanical advantage to the operator. Severed portions drop to a storage chamber. Remaining syringe barrel portions may then be discarded into the storage chamber through a movable closure lid providing separate access to the storage chamber. The severed needle and syringe are destroyed to prevent re-use and accidental injury to medical personnel.