发明授权
- 专利标题： Racemization of an .alpha.-methyl-.beta.-acylthiopropionic acid
- 专利标题（中）： α-甲基-β-酰基硫代丙酸的外消旋化
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申请号： US279706申请日： 1981-07-02
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公开(公告)号： US4411836A公开(公告)日： 1983-10-25
- 发明人: Naohito Ohashi , Shoji Nagata , Junki Katsube
- 申请人： Naohito Ohashi , Shoji Nagata , Junki Katsube
- 申请人地址： JPX Osaka
- 专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人地址： JPX Osaka
- 优先权： JPX54-29548 19790313
- 主分类号： C07B55/00
- IPC分类号： C07B55/00 ; C07B31/00 ; C07C67/00 ; C07C325/00 ; C07C327/20 ; C07C327/32 ; C07D207/16 ; C07C153/023
摘要：
This invention relates to a process for the optical resolution of DL-.alpha.-methyl-.beta.-acylthiopropionic acids of the formula [I], ##STR1## wherein R is a lower alkyl group having 1-4 carbon atoms, phenyl or substituted phenyl bearing methyl or chloro radical; a method for the racemization of an optically active .alpha.-methyl-.beta.-acylthiopropionic acid of the formula [Ia], ##STR2## wherein R is as defined above; and a process for the synthesis of captopril of the formula [II], ##STR3## using the D-acid [Ia] as an intermediate.The optically active .alpha.-methyl-.beta.-acylthiopropionic acids are useful as intermediates for the production of medicines, for example, captopril or its congeners.
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