发明授权
- 专利标题： Azaprostacyclins, their preparation and pharmaceutical use
- 专利标题（中）： 阿沙普罗环素，其制备和药物用途
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申请号： US350674申请日： 1982-02-22
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公开(公告)号： US4446147A公开(公告)日： 1984-05-01
- 发明人: Norbert Schwarz , Werner Skuballa , Helmut Vorbrueggen , Jorge Casals-Stenzel , Ekkehard Schillinger , Michael H. Town
- 申请人： Norbert Schwarz , Werner Skuballa , Helmut Vorbrueggen , Jorge Casals-Stenzel , Ekkehard Schillinger , Michael H. Town
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3107100 19810220
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/403 ; A61K31/557 ; A61P7/02 ; A61P9/10 ; A61P9/12 ; A61P11/08 ; C07C57/03 ; C07C57/13 ; C07C57/26 ; C07C57/52 ; C07C405/00 ; C07D209/52 ; C07D307/935 ; C07F9/40
摘要：
Azaprostacyclins of Formula I ##STR1## wherein R.sub.1 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or a phenacyl residue optionally substituted on the phenyl ring by bromine, phenyl, alkoxy, or dialkoxy,W is a free or functionally modified carbonyl group or a ##STR2## wherein R.sub.8 is hydrogen or alkyl of 1-5 carbon atoms and R.sub.9 is hydrogen or a readily cleavable ether or acyl residue and wherein the OR.sub.9 -group can be in the .alpha.- or .beta.-position,R.sub.2 is a free or functionally modified hydroxy group.
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