发明授权
- 专利标题： Optically active nicotine analogs and process for their preparation
- 专利标题（中）： 光学活性尼古丁类似物及其制备方法
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申请号： US377989申请日： 1982-05-13
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公开(公告)号： US4452984A公开(公告)日： 1984-06-05
- 发明人: William B. Edwards, III
- 申请人： William B. Edwards, III
- 申请人地址： NY New York
- 专利权人： Philip Morris, Inc.
- 当前专利权人： Philip Morris, Inc.
- 当前专利权人地址： NY New York
- 主分类号： C07D401/04
- IPC分类号： C07D401/04
摘要：
This invention provides a process for the preparation of cotinine and nicotine analogs containing substituents on pyrrolidinone/pyrrolidine ring at the 3' position of cotinine and at the 4' and 5' position of nicotine.The process proceeds via a first step preparation of a cotinine intermediate which is represented by the formula: ##STR1## wherein M is an alkali metal cation.
公开/授权文献
- US4916125A Method of treating migraine 公开/授权日：1990-04-10
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