发明授权
US4460581A (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
失效
(1-羟基-2-氨基 - 烷基)取代的苯并恶嗪酮和苯并恶唑啉酮
- 专利标题: (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
- 专利标题(中): (1-羟基-2-氨基 - 烷基)取代的苯并恶嗪酮和苯并恶唑啉酮
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申请号: US433681申请日: 1982-10-12
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公开(公告)号: US4460581A公开(公告)日: 1984-07-17
- 发明人: Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner
- 申请人: Kurt Schromm , Anton Mentrup , Ernst-Otto Renth , Armin Fugner
- 申请人地址: DEX Ingelheim am Rhein
- 专利权人: Boehringer Ingelheim KG
- 当前专利权人: Boehringer Ingelheim KG
- 当前专利权人地址: DEX Ingelheim am Rhein
- 主分类号: C07D263/58
- IPC分类号: C07D263/58 ; C07D265/36 ; C07D413/12 ; A61K31/47
摘要:
Compounds of the formula ##STR1## wherein A is a single bond, ##STR2## R.sub.1 is --OH, --0--acyl, chlorine or hydrogen; R.sub.2 is hydrogen, methyl or ethyl;R.sub.3 is ##STR3## m is 2, 3 or 4; n is 1, 2 or 3;R.sub.4 is hydrogen or lower alkyl;R.sub.5 is hydrogen, lower alkyl or, when R.sub.4 is hydrogen, also phenyl;R.sub.6, R.sub.7 and R.sub.8 are each hydrogen or methyl;R.sub.9 is hydrogen, --Ar, --OAr or --NH--CO--Ar;Ar is ##STR4## R.sub.10, R.sub.11 and R.sub.12 which may be identical to or different from each other, are each hydrogen, hydroxyl, methyl, methoxy, halogen, methylenedioxy, --NH--R.sub.13 or --CONH.sub.2 ; andR.sub.13 is hydrogen, acyl or lower alkylsulfonyl;and non-toxic, pharmaceutically acceptable acid addition salts thereof; the compounds as well as their salts are useful for the treatment of asthma, bronchitis, urticaria, conjunctivities, hay fever, colds and cardiovascular disorders, and for relaxation of the uterine musculature.
公开/授权文献
- US6107986A Display 公开/授权日:2000-08-22
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