发明授权
- 专利标题: Cephalosporin derivatives and use as antimicrobial agents
- 专利标题(中): 头孢菌素衍生物并用作抗微生物剂
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申请号: US390323申请日: 1982-06-21
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公开(公告)号: US4477448A公开(公告)日: 1984-10-16
- 发明人: Helmut Hamberger , Hans Fliri
- 申请人: Helmut Hamberger , Hans Fliri
- 申请人地址: CHX Basel
- 专利权人: Sandoz Ltd.
- 当前专利权人: Sandoz Ltd.
- 当前专利权人地址: CHX Basel
- 优先权: CHX1545/79 19790216; CHX174/80 19800110
- 主分类号: C07D231/12
- IPC分类号: C07D231/12 ; C07D231/14 ; C07D231/18 ; C07D231/38 ; C07D231/40 ; C07D501/20 ; A61K31/545 ; C07D501/56
摘要:
Novel compounds of formula I, ##STR1## in which R.sub.1 is hydrogen, alkyl, phenylalkyl, carbalkoxyalkyl, acyl, carboxyalkyl, alkoxyalkyl, hydroxyalkyl, cyanoalkyl, or carbamoylalkyl,R.sub.2 is hydrogen, pivaloyloxymethyl or the residue of an easily splittable ester grouping,R.sub.3 is a pyrazolyl radical, unsubstituted or mono- or di-substituted by alkyl, phenyl, alkoxy, alkylthio, carboxy, carboxyalkyl, carbamoyl, carbamoylalkyl, alkylsulphonyl, azido, acylamino, hydrazino, acylhydrazino alkylidenehydrazino, phenylidenehydrazino, in which the phenyl nucleus is unsubstituted or substituted by NH.sub.2, lower alkoxy or lower alkyl, furylidenehydrazino, carbalkoxy or a group R.sub.5 R.sub.6 N--, in which R.sub.5 and R.sub.6 are the same or different and are hydrogen or alkyl, provided that the nitrogen atoms and the 4-position of the pyrazole nucleus are either unsubstituted or substituted by alkyl, phenyl, or carbalkoxy, andR.sub.4 is hydrogen, acetoxy, carbamoyloxy or --S--Rh, in which Rh is a heterocyclic radical.
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