发明授权
- 专利标题: Chemical compounds
- 专利标题(中): 化合物
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申请号: US536024申请日: 1983-09-26
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公开(公告)号: US4507487A公开(公告)日: 1985-03-26
- 发明人: Hajime Kamachi , Jun Okumura , Takayuki Naito , Masahisa Oka , Haruhiro Yamashita
- 申请人: Hajime Kamachi , Jun Okumura , Takayuki Naito , Masahisa Oka , Haruhiro Yamashita
- 申请人地址: NY New York
- 专利权人: Bristol-Myers Company
- 当前专利权人: Bristol-Myers Company
- 当前专利权人地址: NY New York
- 主分类号: C07D277/38
- IPC分类号: C07D277/38 ; C07D501/00 ; C07D277/42
摘要:
Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 is a straight or branched chain alkyl group containing from 1 to 4 carbon atoms, allyl, 2-butenyl, 3-butenyl, propargyl, 2-butynyl, 3-butynyl, cycloalkyl containing from 3 to 6 carbon atoms or a group of the formula ##STR2## in which R.sup.3 and R.sup.4 each are independently hydrogen, methyl or ethyl, or R.sup.3 and R.sup.4, taken together with the carbon atom to which they are attached, may be a cycloalkylidene ring containing from 3 to 6 carbon atoms or a substituted cyclobutylidene ring of the formula ##STR3## wherein X is halogen, hydroxy or (lower)alkoxy, and R.sup.5 and R.sup.6 each are independently hydrogen, halogen, amino, carbamoyl, acylamino, acyloxy, (lower)alkyl, (lower)alkenyl, (lower)alkoxy, (lower)alkylamino or (lower)alkylthio, in which each (lower)alkyl, (lower)alkoxy, (lower)alkylamino or (lower)alkylthio group may contain 1 or 2 substituents selected from amino, carboxy, halogen and nontoxic pharmaceutically acceptable acid addition salts, physiologically hydrolyzable esters and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.
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