发明授权
- 专利标题: Hydrogel surface of urological prosthesis
- 专利标题(中): 泌尿系假体水凝胶表面
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申请号: US495698申请日: 1983-05-18
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公开(公告)号: US4527293A公开(公告)日: 1985-07-09
- 发明人: Eugene C. Eckstein , Norman L. Block , Jacob Kline , Leonard Pinchuk
- 申请人: Eugene C. Eckstein , Norman L. Block , Jacob Kline , Leonard Pinchuk
- 申请人地址: FL Coral Gables
- 专利权人: University of Miami
- 当前专利权人: University of Miami
- 当前专利权人地址: FL Coral Gables
- 主分类号: A61L27/34
- IPC分类号: A61L27/34 ; A61M25/00 ; C08F220/54 ; C08J7/04
摘要:
Disclosed is a urological device comprising a polymeric prosthesis coated on its surface by a grafted or interpenetrated hydrogel copolymer comprising 2-hydroxyethyl methacrylate, methacrylic acid, and a crosslinking agent, wherein each constituent of said copolymer is present in an amount selected from a defined range of mole fraction %. The hydrogel exhibits a shrink/swell behavior which varies with changing urine composition such that the polymer undergoes swelling and collapse in rapid response to said change and thereby prevents calcium encrustation. Also disclosed is a method for making the device.