发明授权
- 专利标题: Amidine compounds and anticomplement agent comprising same
- 专利标题(中): 脒化合物和包含其的抗补体剂
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申请号: US572269申请日: 1984-01-20
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公开(公告)号: US4532255A公开(公告)日: 1985-07-30
- 发明人: Setsuro Fujii , Toshiyuki Okutome , Toyoo Nakayama , Takashi Yaegashi , Masateru Kurumi
- 申请人: Setsuro Fujii , Toshiyuki Okutome , Toyoo Nakayama , Takashi Yaegashi , Masateru Kurumi
- 申请人地址: JPX Tokyo
- 专利权人: Torii & Co., Ltd.
- 当前专利权人: Torii & Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX55-128269 19800916; JPX56-64942 19810428
- 主分类号: C07C249/02
- IPC分类号: C07C249/02 ; A61K31/155 ; C07C257/18 ; C07C279/18 ; C07D317/68 ; C07C101/00 ; A61K31/34 ; C07C101/48
摘要:
Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-C1 (C1r, C1s) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula ##STR2## with 6-amidino-2-naphthol and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.
公开/授权文献
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