发明授权
- 专利标题： Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
- 专利标题（中）： 基于亲水性鉴定和制备抗原和过敏原上的表位
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申请号： US461802申请日： 1983-01-28
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公开(公告)号： US4554101A公开(公告)日： 1985-11-19
- 发明人: Thomas P. Hopp
- 申请人： Thomas P. Hopp
- 申请人地址： NY New York
- 专利权人： New York Blood Center, Inc.
- 当前专利权人： New York Blood Center, Inc.
- 当前专利权人地址： NY New York
- 主分类号： A61K39/39
- IPC分类号： A61K39/39 ; C07K14/02 ; A61K37/00
摘要：
An immunoglobulin is provided which consists essentially of a mono-specific, hetero-molecular antibody which is mono-specific to a single antigenic or allergenic determinant. The antibody is specific to the H-epitope of a protein antigen or allergen. The H-epitope is defined by a sequence of at least six amino acids corresponding to the sequence of such amino acids in the protein antigen or allergen where the greatest local average hydrophilicity of the protein antigen or allergen is found.
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