发明授权
- 专利标题： N.sub.b Quaternary derivatives of ajmaline and isoajmaline, methods and intermediate products in the manufacture of their derivatives and method of using same and pharmaceutical compositions thereof
- 专利标题（中）： Nb氧化锰和异亚氨酸的季铵盐衍生物，制备其衍生物的方法和中间产物及其使用方法及其药物组合物
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申请号： US615757申请日： 1984-05-31
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公开(公告)号： US4554274A公开(公告)日： 1985-11-19
- 发明人: Wolfgang Kehrbach , Joachim Wegener , Ulrich Kuehl , Renke Budden , Gerd Buschmann
- 申请人： Wolfgang Kehrbach , Joachim Wegener , Ulrich Kuehl , Renke Budden , Gerd Buschmann
- 申请人地址： DEX Hanover
- 专利权人： Kali-Chemie Pharma GmbH
- 当前专利权人： Kali-Chemie Pharma GmbH
- 当前专利权人地址： DEX Hanover
- 优先权： DEX2941529 19791013
- 主分类号： C07D461/00
- IPC分类号： C07D461/00 ; A61K31/435 ; A61K31/437 ; A61K31/4375 ; A61P9/06 ; C07D471/22 ; C07D455/00 ; C07D471/08
摘要：
New quaternary derivatives of 10-bromoajmaline and 10-bromoisoajmaline are disclosed which exhibit antiarrhythmic and adrenolytic properties and which have the formula I ##STR1## wherein R represents a carbon-attached organic group containing 1 to 10 carbon atoms and A.sup.- represents an acid anion as well as pharmaceutical formulations thereof and processes and intermediates for their preparation.
公开/授权文献
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