A machine tool for flat workpieces such as sheet material includes at least one work station, a first guidance assembly with a workpiece holding device movable in at least one direction relative to the work station and a second guidance assembly with a workpiece holding device independently operable in addition to, or alternatively with, the first workpiece holding device and adapted to be engaged with the workpiece so as to effect its movement independently of or concurrently with the first workpiece holding device. The machine tool desirably includes a computer control for operating the tool work station and the workpiece holding devices, and each of such workpiece holding devices includes at least a pair of workpiece clamping elements with adjustable spacing therebetween. The machine tool may include a pair of machine frames with cantilevered portions extending oppositely of each other and each providing at least one work station or a portion thereof.