A quick change tool retention device for attachment to a power operated mechanism, such as a power operated hand drill, provided with a body portion and a release means attached to a spring-biased leg portion so that a tool, provided with a groove for interlock with the leg portion, can be brought into a keyway and locked in place until such time as the release button is depressed, thereby depressing the leg portion against the spring biasing and releasing the tool from retention via the groove.