发明授权
US4593047A Process for the preparation of 3-trifluoromethyl-and
2,5-dimethyl-4'-hdyroxy-.alpha.-ethyl-benzhydrol, and pharmaceutical
compositions containing them
失效
制备3-三氟甲基 - 和2,5-二甲基-4'-羟基-α-乙基 - 二苯甲醛的方法和含有它们的药物组合物
- 专利标题： Process for the preparation of 3-trifluoromethyl-and 2,5-dimethyl-4'-hdyroxy-.alpha.-ethyl-benzhydrol, and pharmaceutical compositions containing them
- 专利标题（中）： 制备3-三氟甲基 - 和2,5-二甲基-4'-羟基-α-乙基 - 二苯甲醛的方法和含有它们的药物组合物
-
申请号： US565835申请日： 1983-12-27
-
公开(公告)号： US4593047A公开(公告)日： 1986-06-03
- 发明人: Edit Toth , Jozsef Torley , Gyorgy Fekete , Laszlo Szporny , Laszlo Vereczkey , Eva Palosi , Imre Klebovich , Pal Vittay , Sandor Gorog , Istvan Hajdu
- 申请人： Edit Toth , Jozsef Torley , Gyorgy Fekete , Laszlo Szporny , Laszlo Vereczkey , Eva Palosi , Imre Klebovich , Pal Vittay , Sandor Gorog , Istvan Hajdu
- 申请人地址： HUX Budapest
- 专利权人： Richter Gedeon Vegyeszeti Cyar RT
- 当前专利权人： Richter Gedeon Vegyeszeti Cyar RT
- 当前专利权人地址： HUX Budapest
- 优先权： HUX4186/82 19821228
- 主分类号： A61K31/05
- IPC分类号： A61K31/05 ; A61K31/047 ; A61P25/30 ; C07C27/00 ; C07C29/143 ; C07C37/055 ; C07C37/20 ; C07C39/12 ; C07C39/24 ; C07C39/367 ; C07C67/00 ; A61K31/065
摘要：
The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics nor their manufacturing processes have been disclosed in the known publications.3-Trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.
公开/授权文献
- US5652996A Hand held cleaner with swiveling nozzle 公开/授权日：1997-08-05