发明授权
US4594348A Use of some
2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-D]imidazole
derivatives and their pharmaceutically acceptable salts in the
treatment of cardiovascular diseases
失效
一些2- [2- [4-苯基-1-哌嗪基]乙基] -1H-萘并[1,2-D]咪唑衍生物及其药学上可接受的盐在治疗心血管疾病中的用途
- 专利标题： Use of some 2-[2-[4-phenyl-1-piperazinyl]ethyl]-1H-naphth-[1,2-D]imidazole derivatives and their pharmaceutically acceptable salts in the treatment of cardiovascular diseases
- 专利标题（中）： 一些2- [2- [4-苯基-1-哌嗪基]乙基] -1H-萘并[1,2-D]咪唑衍生物及其药学上可接受的盐在治疗心血管疾病中的用途
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申请号： US698653申请日： 1985-02-06
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公开(公告)号： US4594348A公开(公告)日： 1986-06-10
- 发明人: Emilio Toja , Domenico Barone , Emiliana Baldoli
- 申请人： Emilio Toja , Domenico Barone , Emiliana Baldoli
- 申请人地址： ITX Milan
- 专利权人： Gruppo Lepetit S.p.A.
- 当前专利权人： Gruppo Lepetit S.p.A.
- 当前专利权人地址： ITX Milan
- 优先权： GBX8403141 19840207
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; A61K31/4184 ; A61K31/495 ; A61K31/496 ; A61P9/12 ; C07D235/02 ; A61K31/50
摘要：
The present invention is directed to a new pharmacological use of some known naphthoimidazole derivatives. More particularly, the compounds of the invention are 2-[2-(4-phenyl-1-piperazinyl)ethyl]-1H-naphtho[1,2-d]imidazoles of formula ##STR1## wherein R is selected from methyl and 1-methylethyl and R.sup.1 is selected from hydrogen, chloro, methoxy and trifluoromethyl and the pharmaceutically acceptable acid addition salts thereof and possess antihypertensive activity.
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