发明授权
- 专利标题: Lipoxygenase inhibiting compounds
- 专利标题(中): 脂氧合酶抑制化合物
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申请号: US727465申请日: 1985-04-26
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公开(公告)号: US4608390A公开(公告)日: 1986-08-26
- 发明人: James B. Summers, Jr.
- 申请人: James B. Summers, Jr.
- 申请人地址: IL North Chicago
- 专利权人: Abbott Laboratories
- 当前专利权人: Abbott Laboratories
- 当前专利权人地址: IL North Chicago
- 主分类号: C12N9/99
- IPC分类号: C12N9/99 ; A61K31/13 ; A61K31/165 ; A61K31/195 ; A61K31/215 ; A61P11/00 ; A61P17/00 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07C67/00 ; C07C239/00 ; C07C259/06 ; C07C83/10 ; A61K31/04 ; A61K31/185
摘要:
Compounds of the formula ##STR1## where X is selected from hydrogen, C.sub.1 to C.sub.22 alkyl or alkenyl, or an electron withdrawing group;n=0 or 1 and m=0, 1, 2 or 3; but n and m are not O simultaneously;R.sub.1 and R.sub.2 independently are hydrogen, C.sub.1 to C.sub.6 alkyl, an electron withdrawing group, or R.sub.4 ;R.sub.3 is H, C.sub.1 to C.sub.6 alkyl or cycloalkyl, or R.sub.4 ; andR.sub.4 independently at each occurrence, has the formula ##STR2## where Y is hydrogen or an electron withdrawing group; and wherein M is a pharmaceutically acceptable cation, are potent inhibitors of lipoxygenase enzymes.
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