发明授权
- 专利标题： Process for brominating ergot alkaloids
- 专利标题（中）： 溴化麦角生物碱的工艺
-
申请号： US141304申请日： 1980-04-18
-
公开(公告)号： US4609731A公开(公告)日： 1986-09-02
- 发明人: Milan Jurgec , Rudolf Rucman , Branko Stanovnik , Miha Tisler
- 申请人： Milan Jurgec , Rudolf Rucman , Branko Stanovnik , Miha Tisler
- 申请人地址： CHX Basel
- 专利权人： Sandoz Ltd.
- 当前专利权人： Sandoz Ltd.
- 当前专利权人地址： CHX Basel
- 主分类号： C07D457/04
- IPC分类号： C07D457/04 ; C07D457/06 ; C07D519/02
摘要：
The present invention provides an improved process for the production of a compound of formula I ##STR1## wherein R.sub.1 is carboxyl, alkoxy(C.sub.1-5)carbonyl, amido, alkyl(C.sub.1-5)amido, di(alkyl(C.sub.1-5)amido or an amido radical of formula II ##STR2## wherein R.sub.a is alkyl(C.sub.1-4),R.sub.b is alkyl(C.sub.1-4) or benzyl, andR.sub.2 is hydrogen or alkyl(C.sub.1-4), andeitherR.sub.3 is hydrogen and R.sub.4 is hydrogen or alkoxy(C.sub.1-4)orR.sub.3 and R.sub.4 together are a single bond,characterized in that a compound of formula III ##STR3## wherein R.sub.1 to R.sub.4 are as defined above,is brominated with a bromine complex of 3-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine.
公开/授权文献
信息查询
